LymphedemaV1, Main, Exploration, bibRecord, 00E664

Cloned antigen genes of Brugia filarial parasites.

Identifieur interne : 00E664 ( Main/Exploration ); précédent : 00E663; suivant : 00E665

Cloned antigen genes of Brugia filarial parasites.

Auteurs : M E Selkirk [Royaume-Uni] ; P J Rutherford ; D A Denham ; F. Partono ; R M Maizels

Source :

Biochemical Society symposium [ 0067-8694 ] ; 1987.

RBID : pubmed:3332770

Descripteurs français

KwdFr :
- Animaux, Antigènes d'helminthe (génétique), Brugia (génétique), Brugia (immunologie), Données de séquences moléculaires, Filariose lymphatique (immunologie), Humains, Protéines du choc thermique (génétique), Séquence d'acides aminés.
MESH :
- génétique : Antigènes d'helminthe, Brugia, Protéines du choc thermique.
- immunologie : Brugia, Filariose lymphatique.
- Animaux, Données de séquences moléculaires, Humains, Séquence d'acides aminés.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Antigens, Helminth (genetics), Brugia (genetics), Brugia (immunology), Elephantiasis, Filarial (immunology), Heat-Shock Proteins (genetics), Humans, Molecular Sequence Data.
MESH :
- chemical , genetics : Antigens, Helminth, Heat-Shock Proteins.
- genetics : Brugia.
- immunology : Brugia, Elephantiasis, Filarial.
- Amino Acid Sequence, Animals, Humans, Molecular Sequence Data.

Abstract

Human lymphatic filariasis is a chronic, potentially debilitating disease caused by Brugia and Wuchereria species of parasitic nematodes. The spectrum of clinical manifestations appears to be related to the immune response of individuals to invasive larvae, adult worms and circulating first-stage larvae (microfilariae). Potential immunopathological outcomes place constraints on vaccine development, emphasizing the need to understand the basis of immunity and pathology. Clones coding for a number of distinct antigenic proteins of Brugia pahangi and Brugia malayi have been isolated via immunological screening of a cDNA expression library. A small number of these expressed peptides show exclusive reactivity with antibody from amicrofilaraemic, potentially immune individuals. Surprisingly, a dominant immunogen isolated with human antibody is the filarial parasite homologue of heat shock protein (hsp) 70. This protein is constitutively expressed in both insect- and mammalian-dwelling parasitic stages, but does not appear to presented to the host immune system in intact worms.

PubMed: 3332770

Affiliations:

Le document en format XML

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<term>Brugia (immunologie)</term>
<term>Données de séquences moléculaires</term>
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<front><div type="abstract" xml:lang="en">Human lymphatic filariasis is a chronic, potentially debilitating disease caused by Brugia and Wuchereria species of parasitic nematodes. The spectrum of clinical manifestations appears to be related to the immune response of individuals to invasive larvae, adult worms and circulating first-stage larvae (microfilariae). Potential immunopathological outcomes place constraints on vaccine development, emphasizing the need to understand the basis of immunity and pathology. Clones coding for a number of distinct antigenic proteins of Brugia pahangi and Brugia malayi have been isolated via immunological screening of a cDNA expression library. A small number of these expressed peptides show exclusive reactivity with antibody from amicrofilaraemic, potentially immune individuals. Surprisingly, a dominant immunogen isolated with human antibody is the filarial parasite homologue of heat shock protein (hsp) 70. This protein is constitutively expressed in both insect- and mammalian-dwelling parasitic stages, but does not appear to presented to the host immune system in intact worms.</div>
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Serveur d'exploration sur le lymphœdème

Cloned antigen genes of Brugia filarial parasites.

Cloned antigen genes of Brugia filarial parasites.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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